The journey to a longer life and a longer healthspan does not begin with supplement stacks, hacks, or optimization theater. It points toward avoiding a familiar set of high-impact risks. Across cohort studies, combinations of unhealthy behaviors are associated with substantially higher all-cause and cardiovascular mortality, which is not especially novel advice but remains stubbornly true.[2] The list is familiar because the biology is familiar. Bodies tend to fare better when they are not repeatedly asked to compensate for smoke exposure, inactivity, sleep loss, heavy drinking, social isolation, and chronic neglect. The good news, if that is the word, is that many of these risks are modifiable.